India’s 78th Independence Day: Celebrating Freedom, but the Battle Against Antimicrobial Resistance Continues.
India’s 78th Independence Day: Celebrating Freedom, but the Battle Against Antimicrobial Resistance Continues.
Microvioma
2,564 followers
August 15, 2024
On the 78th Independence Day of India, we come together to celebrate our nation’s journey towards freedom, progress, and development. However, as we rejoice, we must also acknowledge a pressing challenge that still binds us — the growing threat of #AntimicrobialResistance (#AMR). The fight against AMR is one that demands urgent attention and collective action. This unseen enemy threatens to undo decades of medical progress and put millions of lives at risk. If left unchecked, AMR might lead in a post-antibiotic future in which even simple infections can be fatal.
When bacteria, viruses, fungi, and parasites evolve and gain resistance to the medications that are intended to kill them, they grow more powerful and lethal. The misuse and overuse of #antibiotics and other #antimicrobials in humans, animals, and agriculture have accelerated this process, creating #superbugs that defy even the strongest medications.
India, with its large population and complex healthcare challenges, is at the heart of this catastrophe. The sad reality is that AMR is already present and expanding rapidly. Infections that were once manageable with a short course of antibiotics are now untreatable. Hospitals are dealing with outbreaks of drug-resistant diseases that are taking lives and raising healthcare expenses. The repercussions of AMR are serious, and if we do not act now, we risk a future in which routine procedures, childbirth, and even small accidents can be fatal.
This is not a far-fetched dystopia; it is a real possibility if we continue to disregard the threat of AMR. World Health Organization has raised the alarm, listing AMR as one of the top ten global health hazards. The clock is ticking, and the implications of inactivity are too serious to be overlooked.
In India, antibiotic abuse is widespread. In rural places with limited access to skilled healthcare experts, antibiotics are frequently distributed like candy, with no concern for proper diagnosis or dosage. Self-medication and the ready availability of over-the-counter antibiotics in metropolitan areas contribute to the spread of resistant strains. This reckless activity endangers not only individual lives, but the entire population.
The economic impact of AMR is tremendous. Prolonged hospital stays, the demand for more expensive and complex treatments, and rising mortality rates are putting a pressure on an already overcrowded healthcare system. However, the impact extends beyond the healthcare sector. AMR jeopardizes food security, economic stability, and even national security.
The importance of antimicrobial stewardship: The situation is dire, but there is hope.
Antimicrobial Stewardship (AMS) is our most effective protection against the growing threat of AMR. AMS is more than a guideline; it is an urgent call to action. It is about ensuring that antimicrobial medications are used wisely and sparingly, preserving their effectiveness for as long as possible. Every time an antibiotic is used excessively or wrongly, we allow resistant bacteria to grow and spread.
AMS are expressed in the 5 D’s of Antimicrobial Therapy:
- Diagnosis: An accurate and prompt diagnosis is required to establish whether antimicrobial therapy is appropriate and necessary.
- Drug: Choosing the best antibacterial medication to target the infection effectively.
- Dosage: Administering the appropriate dose to maximize efficacy while reducing the risk of resistance.
- Duration: Ensure that the treatment is administered for the appropriate amount of time to completely remove the infection and avoid recurrence.
- De-escalation: Limiting the scope of therapy depending on patient response and microbiological evidence to avoid needless exposure to broad-spectrum antibiotics.
#AMRACE (Antimicrobial Resistance Action Collaborative Engagement) program :
A major initiative in the fight against AMR in India, led by Microvioma as its flagship program, supported by the Bangalore Bioinnovation Centre, is dedicated to tackling AMR through research, education, and advocacy. In collaboration with the Rotary Club of Bangalore (R.I. District 3192), AMRACE is working on raising awareness, promoting research, and influencing policy changes that encourage responsible antimicrobial use.
AMRACE organizes educational campaigns and workshops to inform healthcare professionals, policymakers, and the public about the importance of fighting AMR. By engaging with government officials and international organizations, AMRACE advocates for stronger policies and regulations to ensure that antimicrobials are used responsibly.
A key aspect of AMRACE is its focus on global collaboration. Recognizing that AMR is a problem that transcends borders, the program works with international partners to share knowledge and resources. By fostering partnerships with research institutions, governments, and non-governmental organizations, AMRACE aims to create a unified global response to AMR.
A Global Movement: Antimicrobial Stewards
While AMRACE is making strides in India, it is part of a larger global effort to combat AMR. Global antimicrobial stewards – researchers, healthcare professionals, and governments – are working together to develop new antibiotics, diagnostic tools, and infection prevention strategies. These stewards are also advocating for stronger surveillance systems to track the spread of resistant organisms and ensure a coordinated global response.
Notable global stewards include:
- Dr. Maneesh Paul. S., M. Sc., Ph.D., FIDSA., CEO of Microvioma and Co-Inventor of #Enmetazobactam.
- Dr. Elizabeth Cherian Alliance for Health Promotion (A4HP), Geneva, and International Coordinator at COMHAD, UK.
- Shannon Olsson, Founder and Global Director, the echo network, Denmark.
- Lena Robra, Head of Academic Engagement, Swissnex in India, Consulate General of Switzerland.
- Prof. Y K. Gupta, M.D., Principal Advisor at Global Antibiotic R&D Partnership (GARDP) and President of AIIMS Jammu.
- Dr. Maarten van Dongen, PhD, Founder of AMR Insights.
As we commemorate India’s #78thIndependenceDay, we must remember that our fundamental freedom is under danger from a new and grave enemy. AMR is not only a public health concern; it is a national emergency. The war against AMR will not be simple, but it is one that we must win. Antimicrobial stewardship, initiatives such as AMRACE, and international cooperation are our weapons in this struggle. However, these efforts will only be successful if we all grasp the gravity of the problem and take action. This Independence Day, let us commit to the fight against AMR. The future of our nation, and indeed the world, depends on it.